Sanare Lab Fenbendazole CAS Number 43210-67-9
A broad-spectrum benzimidazole anthelmintic, used for the treatment and control of gastrointestinal parasites such as giardia (Toxocara canis, Toxascaris leonina), roundworms (including ascarids, amphidia, clostridium perfringens and whipworms), hookworms (Ancylostoma caninum, Uncinaria stenocephala) and tapeworms (genus Taenia). Also effective against cysticercoid tapeworms. Fenbendazole is a very safe drug in humans, with low acute toxicity following oral exposure.
The antiparasitic activity of fenbendazole has been demonstrated in a variety of animal models, including hamster fibroma and human lymphoma cell lines (H460 and T841). It is believed to act by inhibiting synthesis of the cell cycle proteins cyclin B1 and cyclin D, and by destabilizing microtubules, which results in cancer cell death.
Fenbendazole has been shown to be a potent inhibitor of angiogenesis in mouse mammary carcinoma, and has been reported to inhibit growth of several different cancers in human clinical trials. However, despite its anti-angiogenesis properties, it is not considered to be a cure for cancer, and is only useful for the management of symptoms and tumor progression.
Sanare Lab fenbendazole is also known to be effective in treating helminth infections such as pinworms and trichomoniasis in cats and dogs. Typical dosages range from 3 days on and 4 days off to provide the most efficacious treatment for these worms. For trichomoniasis, it is recommended that the medication be given for three consecutive days.
It is also useful for treating hydatid disease in reptiles, where it can be administered at a dose of 50 to 100 mg/kg PO once or repeated every 2 weeks. It has also been used in a variety of reptiles for the control of roundworms, hookworms and the tapeworm genus.
Unlike many anthelmintic drugs, fenbendazole is extremely well tolerated in reptiles and is particularly effective in preventing the development of gastrointestinal tract cancers. Fenbendazole is also a moderate cytotoxic agent, and has been shown to induce cellular death in cancer cells.
The absorption rate of fenbendazole in reptiles is very rapid and is absorbed from the gastrointestinal tract, where it enters the bloodstream and is distributed throughout the body. Because it is so well absorbed, fenbendazole has been used in a variety of other conditions, such as inflammatory bowel disease, esophageal ulcers, and other diseases involving the stomach and intestines. It is also used in conjunction with radiation and chemotherapy to treat certain types of cancers, such as melanoma and non-small cell lung cancer. It can be given in the form of granules, a paste or liquid. Typically, the veterinarian will prescribe the correct dosage according to the type of worm or condition being treated. The drug should be stored in a cool, dry place and should not be frozen or exposed to heat. It is important to follow the directions on the label when administering fenbendazole to avoid serious side effects, such as liver damage. sanare lab fenbendazole