Tretinoin and fiber proliferative disease
The initial study of tretinoin is more concentrated in the tumor effects, especially for acute promyelocytic leukemia. Now it has been successfully used in clinical trials. In recent years, the kidney, liver, lung, and other appropriate animal model experiments have confirmed retinoic acid’s role in anti-fibrosis and cell proliferation. The cosmetic raw material suppliers also make the tretinoin applied in treating dermatosis of fibroblasts proliferation and excessive collagen deposition.
Tubulointerstitial fibrosis is the common pathway for a variety of chronic kidney disease to end stage renal failure. The degree of tubulointerstitial damage and glomerular filtration rate was negatively correlated with prognosis than the glomerular lesions. Classic unilateral ureteral obstruction model, given retinoic acid intervention, and 7 days after the detection of relevant indicators, the results show that retinoic acid can significantly reduce the degree of interstitial fibrosis, reducing the infiltration of mononuclear macrophages, lowered the TGF- ²1 and procollagen I mRNA expression, thus contributing to the prevention and treatment of fibrosis. Many Chinese scholars have research in all angles. The results show that it has a protective effect on tubulointerstitial fibrosis.
The occurrence of liver fibrosis is caused by the synthesis and degradation of extracellular matrix components imbalance in the liver. Modern studies have shown that the Ito located in the sinusoidal function of storage and metabolic VitA, collagen production in liver fibrosis cells. RA can reduce the CCl4-induced hepatic fibrosis in rats `, type b collagen and other extracellular matrix accumulation in the liver, inhibition of changes in fat-storing cells to myofibroblasts. In vitro experimental studies have shown that retinoic acid can inhibit Ito 3H-TdR incorporation and reduce the primary cultured fat-storing the DNA, RNA content. A recent study showed that small doses of all-trans retinoic acid by reducing the expression of chronic alcoholic liver injury in rat liver fibrogenesis factor of TGF-²1 and CTGF and Colla1 inhibit the formation of early alcoholic liver fibrosis. Seen in this light, the RA is expected to become a new drug for the treatment of liver fibrosis. Tretinoin 0.1% Gel